1
The remainder of the sequence corresponded to the 3'-region of the mRNA downstream from the termination codon.
2
Furthermore, the most C-terminally located premature termination codon mutation fails to rescue the progenitor cell proliferation defect in hippocampal slice cultures from Bcl11b-deficient mice.
3
RNA analysis revealed that an alternative splice site within exon 1 was used leading to a premature termination codon within exon 2.
4
Affected animals carry a mutation that predicts a premature termination codon in exon 8 and a peptide that is 5% the size of normal dystrophin.
5
Due to premature termination codons, none encodes functional protein.
1
However, the stop codon is preceded by a run of 11 consecutive adenosines.
2
The single-base pair mutation causes a frameshift, which results in premature stop codon.
3
This duplication results in a frame shift and premature stop codon.
4
A premature stop codon UGA appeared to be most responsive to PTC124 treatment.
5
The 5'UTR contains two false AUG initiation codons followed by a stop codon.
6
One variant introduces an early stop codon in MLL3, which predicts complete loss-of-function.
7
On exposure to cre-recombinase a stop codon is generated immediately downstream in exon 6.
8
This bias near the stop codon is partially release-factor specific.
9
One WP sequence with an HBx stop codon suggested infectivity.
10
Addition of Sec into a protein is achieved by recoding of the UGA stop codon.
11
Most RS-exons contain a premature stop codon such that their inclusion can decrease mRNA stability.
12
The first variant generates a premature stop codon (NCBI accession no.
13
In all these transcripts the open reading frame is maintained until the same stop codon.
14
No correlation was found between the spermiogram and the changes leading to the stop codon.
15
Tryptophan acts by inhibiting Release Factor 2-mediated cleavage of this peptidyl-tRNA at the tnaC stop codon.
16
Additionally, stop codon-gain variants in two intronless genes were not expressed, an unexpected outcome given previous studies.